What is a genetic disorder that affects both the respiratory and digestive systems?

Cystic fibrosis is a genetic disorder that primarily affects the respiratory and digestive systems due to mutations in the CFTR gene. This condition results in the production of thick and sticky mucus that can obstruct airways, leading to respiratory issues such as chronic lung infections and difficulty breathing.

In the digestive system, the thick mucus can block the pancreatic ducts, inhibiting the proper release of digestive enzymes, which can lead to malabsorption of nutrients and related complications. These combined effects on both systems are characteristic of cystic fibrosis, making it a distinct and complex disorder with significant implications for the health and quality of life of affected individuals.

While Down syndrome, Huntington's disease, and sickle cell anemia are all genetic conditions, they do not primarily affect both the respiratory and digestive systems in the same manner as cystic fibrosis. Down syndrome is a chromosomal disorder that affects development and has various associated health issues, but does not specifically target these systems. Huntington's disease primarily impacts neurological function over time, while sickle cell anemia mainly affects blood and circulation. Hence, none of these conditions share the same dual impact on the respiratory and digestive systems as cystic fibrosis does.