What is a potential consequence of tricyclic antidepressant medications inhibiting reuptake?

When tricyclic antidepressant medications inhibit the reuptake of neurotransmitters such as norepinephrine and serotonin, one of the notable effects can be increased arousal, particularly in relation to their stimulating properties. This mechanism involves prolonging the availability of these neurotransmitters in the synaptic cleft, which can enhance mood and energy levels.

This increased availability can heighten arousal, improving symptoms of depression and anxiety in some patients, providing them with more energy and alertness. In contrast, decreased heart rate, decreased blood pressure, and mild sedation typically align with the effects of other medications or conditions but are not the primary consequences of the reuptake inhibition associated with tricyclic antidepressants.